“Cannabidiol (CBD) is a major phytocannabinoid present in the Cannabis sativa plant. It lacks the psychotomimetic and other psychotropic effects that the main plant compound Δ(9)-tetrahydrocannabinol (THC) being able, on the contrary, to antagonize these effects.-^v- It is now clear that CBD has therapeutic potential over a wide range of non-psychiatric and psychiatric disorders such as anxiety, depression and psychosis.-^v- activation of TRPV1 channels may help us to explain the antipsychotic effect and the bell-shaped dose-response curves commonly observed with CBD -^v-inhibition of adenosine uptake, inverse agonism at CB2 receptor, CB1 receptor antagonism, GPR55 antagonism, PPARγ receptors agonism, intracellular (Ca(2+)) increase”
The effects CBD on the above mentioned receptors will be more closely looked at in future post and literature review. When taking receptor activation you still have to take into consideration the neuronal function and if the neuron when synapsed exerts an inhibitory or excitatory response. Behavioral effects will be contingent on the proper dosing as well as the affinity to each receptors at particular doses. When CBD binds, or any chemical causing an action potential or cascading effects, the binding chemical, called ligand, sticks to the receptor for a certain length. Different receptors have different binding strengths and lengths. This causes different dosages to have different affects. A longer binding of PPAR-gamma increases mitochondrial activity increasing calories burned, while inhibition of adenosine uptake (this mechanism is used by many barbiturates, benzodiazepines, and tri-cyclic anti-depressants) causes drowsiness and effects your sleep wake cycle.
Journal Citation (JC)-Campos AC, Moreira FA, Gomes FV, Del Bel EA, Guimarães FS. Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders. Philos Trans R Soc Lond B Biol Sci. 2012;367(1607):3364-3378. doi:10.1098/rstb.2011.0389
”Following the initial report that it blocks the anxiogenic effects of high doses of the main psychoactive compound present in the Cannabis sativa plant, Δ9-tetrahydrocannabinol (THC)”
This is in reference to CBDs anxiolytic (anxiety reducing properties) while high doses cause Anxiogenic meaning creating anxiety. If your one who gets paranoid or has issues with anxiety, THC might not be the most effective means of therapy, according to this Scientific article.
(JC)-Zuardi A. W., Shirakawa I., Finkelfarb E., Karniol I. G. 1982. Action of cannabidiol on the anxiety and other effects produced by delta 9-THC in normal subjects. Psychopharmacology (Berl.) 76, 245–25010.1007/BF00432554 (doi:10.1007/BF00432554)
The bell shapes curve states that an optimal dose is within a certain range and anything greater will actually diminish results. Current scientific literature is done mainly on petri-dishes and lower species animals. Human effects of CBD on anti-inflammitory, anxiolytic, anti-oxident, pain management, diabetes, weight loss, and others chronic and acute diseases will be dependant on persons dosage, age, and weight mainly. CBD-dATA is meant to be a user driven database to create an optimal dose schedule for future refining of therapies. Please contribute to CBD-dATA so we can expand on scientific understanding.